AGILENT HP HPLC DEGASSER / DEGASSING MODULE TROUBLESHOOTING TIPS, ERRORS & REPAIRS:
Mobile Friendly Web Page Can Be Found at this LINK
Examples of Agilent brand HPLC vacuum degassers that we professionally service include:
Agilent STANDALONE Degasser Modules: G1322A, G1379A, G1379B, G4225A, G7122A.
Agilent INTEGRATED Degasser Modules (installed inside the pump): G1311A, G1311B, G1311C, G1312A, G1312B, G1312C, G4204A, G4204B, G4220A, G4220B, G7104A, G7104C, G7111A, G7111B, G7112A, G7112B.
Chiralizer Services offers professional testing and repair services for all Agilent 1100, 1120, 1200, 1220, 1260 and 1290 series vacuum degasser modules (Standalone and Integrated modules). Chiralizer can professionally test, clean and service vacuum degassers for a fraction of the cost charged by Agilent and other vendors. We have three decades of professional HPLC design, maintenance and service experience with these modules. All parts are in stock at reduced prices for fast service turnaround times. Each degasser we professionally test and service includes a warranty.
A Mobile Friendly Degasser Service Web Page Can Be Found at this LINK.
Degasser Problems:
HP/ Agilent Stand Alone Degasser Modules:
RED LED ON = Serious Error and the Degasser is no longer working. This is most often due to a leak in one or more of the vacuum chambers, failure of the pump and/or solenoid valve, or worn / contaminated vacuum tubing. Note: If you work in a regulated environment, then this means your qualified HPLC system is now 'out-of-compliance' and should not be used.
Yellow LED ON continuously after ~ 2 minutes ON time usually indicates that the degasser is not able to meet or maintain the factory vacuum specification. It is probably overdue for service (required at least every 5 years), failing and is 'out-of-compliance'. It should be repaired before more damage and/or flow path contamination result (the LED will turn RED next and shut the system down).
Liquid Coming Out of the front Degasser Vent /exhaust tube: Any liquid, droplets or residue seen exiting the degasser's pump vent tube often indicates that a serious failure has occurred inside the vacuum module (e.g. a loose vacuum line, leaking or ruptured vacuum chamber). If observed, please stop using the degasser at once as continued use may result in even more damage. The vacuum pump and other parts of the vacuum system are now contaminated. The degasser is now 'out-of-compliance' and should be professionally diagnosed and repaired.
Air Bubbles seen Exiting the low pressure translucent tubing from the degasser: This usually indicates that: (1) the flow rate may be set too high; (2) One or more of the low-pressure fittings entering or exiting the degasser are not tightly sealing against the ferrule allowing air to enter the tubing (carefully remove the fitting, check for damage to the threads or ferrule, re-install) or (3) one or more of your degasser's vacuum chambers is damaged. Never replace just the vacuum pump in an HP /Agilent brand system without first fully diagnosing which parts are contaminated and/or damaged. Replacing only the vacuum pump and not all of the damaged parts often leads to complete contamination and damage to the new vacuum pump and other components (a costly mistake). We are experts in this area and understand how these systems operate, how they can fail and how to correctly repair them. Chiralizer Services can correctly diagnose the problem, clean and repair it for far less money than what the original manufacturer or other third party repair facilities charge. We have over 30 years professional experience serving these modules.
HP/ Agilent Integrated Degasser Modules:
Do you see these ERROR CODEs ? Look in the Instrument Logbook. If so, you may have a damaged degasser.
“Degasser Pressure Limit Violation” Error ID: 22032
“Pressure Too Far Above Limit” Error ID 29220
“Degasser Not Ready after 8-minutes, > 180mBar” Error 2244
“Degasser Pressure Output Error” Error 2243
“Pressure Limit Violation” Error 29220
“Degasser Pressure Limit Violation” EE29220-150
“Vacuum cannot be maintained” Error 8014
“Degasser Cannot Read Signal” Error 2243
Liquid Leaking Out of the front Degasser drain: Any liquid, droplets or residue seen exiting the degasser's pump exhaust tube often indicates that a serious failure has occurred inside the vacuum module (e.g. a loose vacuum line, leaking or ruptured vacuum chamber). If observed, please stop using the degasser at once as continued use may result in even more damage. The vacuum pump and other parts of the vacuum system are now contaminated. The degasser is now 'out-of-compliance' and should be professionally diagnosed and repaired.Air Bubbles seen Exiting the low pressure translucent tubing from the degasser to the pump: This usually indicates that: (1) the flow rate may be set too high; (2) One or more of the low-pressure fittings entering or exiting the degasser are not tightly sealing against the ferrule allowing air to enter the tubing (carefully remove the fitting, check for damage to the threads or ferrule, re-install) or (3) one or more of your degasser's vacuum chambers is damaged. Never replace just the vacuum pump in an HP /Agilent brand system without first fully diagnosing which parts are contaminated and/or damaged. Replacing only the vacuum pump and not all of the damaged parts often leads to complete contamination and damage to the new vacuum pump and other components (a costly mistake). We are experts in this area and understand how these systems operate, how they can fail and how to correctly repair them. Chiralizer Services can correctly diagnose the problem, clean and repair it for far less money than what the original manufacturer or other third party repair facilities charge. We have over 30 years professional experience serving these modules.
START THE DEGASSER TROUBLESHOOTING PROCESS BY PERFORMING THESE BASIC CHECKS
Have you properly primed and purged the HPLC system? Make sure that ALL of the VACUUM CHAMBERS / CHANNELS have fresh mobile phase inside them. The degassing system is NOT designed to be operated with air inside any of the vacuum channels. PURGE each of the channels, one-at-a-time, with mobile phase. NEVER plug a chamber because you are not using it (the liquid inside a plugged channel will quickly evaporate leaving air inside).
Are you using ALL of the Degassing Channels? You should be. If you have one or more degasser channels that are not being used, then connect the unused channel(s) in-line to a channel that is being used to keep it filled with fluid at all time. Use a low pressure connection line to connect it in-series (we often call these lines 'C' tubes because they loop back like the letter 'c'). *USE ALL of the degassing channels ALL of the time.
Liquid observed in the vacuum pump’s exhaust Vent Line? If observed, the system may have serious internal damage, one or more damaged degassing membranes (chambers) and/or flow path contamination. The degasser requires professional testing to find out which part or parts require replacement or repair. The vacuum system flow path should be dry at all times.
Is the degasser more than Five years old? If so, it is overdue for professional cleaning and servicing. To prevent flow path contamination and assist the pump to operate properly, resulting in stable baselines, the degasser requires regular service/replacement. Note: Some Agilent brand degassers require servicing in as few as three years (e.g.. G1379A and G1379B and 1260/1290 integrated degassers installed in the pump).
Repair Services Available :
For more information, please send us an email containing your complete contact information, the model and S/N of your degasser (or the pump module it was removed from plus pump serial number, if it is an integrated degasser) and problem(s) observed. If you are in the USA, then we can discuss options and/or forward you a diagnostic quote with shipping return instructions.
HPLC Vacuum Degassing Module Repairs, Vacuum Pumps and Chambers.
Depending on make and model, if well maintained, HPLC vacuum degassers often wear out after three to five years of service. The instrument vendors do not "service" them, they replace them at great cost to you. Note: Never replace just the vacuum pump in a degasser. Doing so will result in the replacement pump being contaminated after installation! If will fail soon after as the original cause of WHY the degasser was not first found. Additionally, all vacuum degasser modules will have a contaminated vacuum flow path after use which must be professionally cleaned before replacement parts can be installed. Failure to professionally diagnose the failure and condition of all internal components before service will result in failure, again, with even more money being spent swapping out parts. It is far less expensive to have professionals at Chiralizer Services test your broken degasser to find out what is actually wrong with it and why it failed. They can provide a service quote to clean and repair it like new at a very low price with FAST turnaround times.
- We stock many replacement parts such as solenoid valves, vacuum control boards, vacuum chambers, vacuum sensors, power supplies, tubing and other related items needed to repair these modules in our shop. Many types of professionally refurbished parts are also available (rebuilt by us, in-house).
Due to the small size and weight of the HP, Agilent brand standalone degassers (i.e. G1322A, G1379A, G1379B, G4225A, G7122A), we suggest you ship the degasser module to us. For integrated degasser modules found inside the Agilent pumps, the internal degasser module must be removed from the pump to send in for service (the degasser is self contained inside a small rectangular black box with SS top cover). Once the degasser module is in our workshop, we can test it to determine what repairs and/or parts are actually needed. We will correctly determine which parts of your degasser are defective and send you a formal report plus service quotation to replace the defective parts and QC test the system. We do charge a nominal diagnostic fee to evaluate and test your degasser, but you retain control over the decision to have it repaired or not. Sometimes a cleaning is all it needs.
Professional Diagnostic Testing of Your Degassing Module is Available;
Repair, Cleaning and/or Replacement of Defective Parts (down to the component level);
Optional High Performance Vacuum Pump and Chamber Upgrade Kits available for some models;
Options for Professionally Refurbished Parts and modules to Save You Money;
Lowest Prices, Highest Quality & Quick Repair Turnaround Times (Usually 1-2 Business days!).
Chiralizer Services, LLC, USA
Email Contact: Sales@HPLCTOOLS.com or Sales@CHIRALIZER.com Phone 1.919.241.4858
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